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Low-dose dipyridamole infusion acutely increases exercise capacity in angina pectoris

A double-blind, placebo controlled crossover stress echocardiographic study

^a Department of Clinical and Experimental Medicine, Cardiology Unit, University of Perugia, Perugia, Italy
^b Institute of Clinical Physiology, CNR, Pisa, Italy

View larger version (24K): [in a new window]   Figure 1 Time (in seconds—ordinal axis) of appearance of wall motion abnormalities at the echocardiographic examination (bottom panel) and of ST segment shift (1 mm) at ergometer test (top panel) after pretreatment with placebo and dipyridamole. Each line represents individual values. Low-dose dipyridamole infusion increases exercise tolerance in chronic stable angina pectoris.

View larger version (19K): [in a new window]   Figure 2 Wall motion score index at rest, peak of exercise stress echo and at 3 min of recovery after pretreatment with placebo (white box) and dipyridamole (black box). Wall motion abnormalities after dipyridamole were significantly less severe and more rapidly recovering in comparison with placebo.