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Hemodynamic comparison of twice daily metoprolol tartrate with once daily metoprolol succinate in congestive heart failure

^a Heart Failure Program, Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA

View larger version (19K): [in a new window]   Figure 1 Hemodynamic indexes of a) pulmonary capillary wedge pressure, b) stroke volume index, c) systemic vascular resistance, and d) stroke work index at baseline (B), peak–2 h after initial drug administration (P), long term trough after 3 months of metoprolol therapy (LT-b) and 2 h after drug readministration (LT-p). Error bars are SEM. P values are designated to show differences from B to 2 h, B to LT-B and from LT-B to LT-P within groups. Symbols under the lines refer to MT and symbols above the lines refer to MS. There were no between group differences for any changes. MS = metoprolol succinate; MT = metoprolol tartrate. *p < 0.001, p < 0.01, p < 0.05.