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Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy

The CARDIGENE study

Laurence Tiret, PhD^*, Christine Mallet, MSc, Odette Poirier, PhD^*, Viviane Nicaud, MA^*, Alain Millaire, MD, PhD, Jean-Brieuc Bouhour, MD, G.érard Roizès, PhD^||, Michel Desnos, MD^¶, Richard Dorent, MD^#, Ketty Schwartz, PhD, François Cambien, MD^*, Michel Komajda, MD^** for the CARDIGENE Group

^* INSERM U525, Paris, France
INSERM SC7, Paris, France
CHR de Lille, Lille, France
CHR de Nantes, Nantes, France
^|| INSERM U249, Montpellier, France
^¶ Hôpital Boucicaut, Paris, France
^# Service de Chirurgie Cardiaque, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
^** Service de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
INSERM U523, Paris, France

View larger version (15K): [in a new window]   Figure 1 Genotypic odds ratios for DCM and 95% confidence intervals, assuming a recessive (left) or dominant (right) genetic model. For all polymorphisms, the major allele was taken as the reference allele, except for ACE I/D where I was the reference allele. For TGFB1 R25P and BNP C-1563T, the recessive model was not considered because of the low frequency of the minor allele.