Effects of long-term therapy with bosentan on the progression of left ventricular dysfunction and remodeling in dogs with heart failure
Takayuki Mishima, MDa,
Mitsuhiro Tanimura, MDa,
George Suzuki, MDa,
Anastassia Todor, MDa,
Victor G. Sharov, MD, PhDa,
Sidney Goldstein, MD, FACCa and
Hani N. Sabbah, PhD, FACCa
a Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan, USA
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Figure 2 Left, Bar graph depicting the mean (±SEM) LV end-diastolic volume (EDV) in untreated control dogs (CON) and in dogs treated with bosentan (BOS). Right, Bar graph depicting the mean (±SEM) LV end-systolic volume (ESV) in untreated control dogs and in dogs treated with bosentan. Solid bars indicate values obtained before initiating treatment and hatched bars to values obtained after three months of follow-up or active therapy. Probability values are based on intragroup pretreatment to post-treatment comparisons.
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Figure 3 Bar graph depicting the mean (±SEM) value of the intragroup change ( ) from pretreatment to post-treatment of LV end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF) in untreated control dogs (solid bars) and in dogs treated with bosentan (hatched bars). Probability values are based on comparisons of change between control and bosentan (treatment effect).
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Figure 1 Bar graph depicting the mean (±SEM) LVEF in untreated control dogs and in dogs treated with bosentan. Solid bars indicate values obtained before initiating treatment (pretreatment); hatched bars indicate values obtained after three months of follow-up or active therapy (post-treatment). Probability values are based on intragroup pretreatment to post-treatment comparisons.
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