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Baroreflex sensitivity and variants of the renin angiotensin system genes

Antti Ylitalo, MD^*, K. E. Juhani Airaksinen, MD^* , Aarno Hautanen, MD, Markku Kupari, MD, Marion Carson, MD, Juha Virolainen, MD, Markku Savolainen, MD, Heikki Kauma, MD, Y. Antero Kesäniemi, MD, Perrin C. White, MD and Heikki V. Huikuri, MD, FACC^*

^* Division of Cardiology, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
Atherosclerosis Research Group, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA

View larger version (20K): [in a new window]   Figure 1 Individual data on baroreflex sensitivity in relation to the –344C/T polymorphism in the promoter of CYP11B2 in women in Population 1. Horizontal lines indicate group mean values. * = ANOVA; CYP11B2 = aldosterone synthase.

View larger version (17K): [in a new window]   Figure 2 Individual data on baroreflex sensitivity in relation to the –344C/T polymorphism in the promoter of CYP11B2 in men in Population 1. Horizontal lines indicate group mean values. * = ANOVA; CYP11B2 = aldosterone synthase.

View larger version (26K): [in a new window]   Figure 3 Baroreflex sensitivity (mean ± SEM) by the –344C/T polymorphism in the promoter of CYP11B2 in age tertiles in women in Population 1. * = ANOVA; CYP11B2 = aldosterone synthase.

View larger version (15K): [in a new window]   Figure 4 Individual data on baroreflex sensitivity in relation to the –344C/T polymorphism in the promoter of CYP11B2 in Population 2. Horizontal lines indicate group mean values. * = ANOVA; CYP11B2 = aldosterone synthase.