A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension
Marius M. Hoeper, MD*,
Horst Olschewski, MD ,
Hossein A. Ghofrani, MD,
Heinrike Wilkens, MD ,
Joerg Winkler, MD ,
Mathias M. Borst, MD||,
Jost Niedermeyer, MD*,
Helmut Fabel, MD*,
Werner Seeger, MD the German PPH Study Group¶
* Departments of Pulmonary Medicine, Hannover Medical School, Hannover, Germany
Department of Internal Medicine, Justus Liebig University, Giessen, Germany
Department of Pulmonary Medicine, University of the Saarland, Homburg, Germany
Department of Internal Medicine, University of Leipzig, Heidelberg, Germany
|| Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
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Figure 1 Comparison of the effects of inhaled nitric oxide (NO, 40 ppm for 15 min) and aerosolized iloprost (14 to 17 µg over 15 min) on pulmonary artery pressure (A), cardiac output (B) and pulmonary vascular resistance (C) in 35 patients with primary pulmonary hypertension. Dots represent the individual responses compared to baseline, expressed as percentage. A location below the line of identity indicates a more pronounced effect of iloprost, while a location above the line of identity reflects a more pronounced effect of NO.
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Figure 2 Time course of the effects of aerosolized iloprost on pulmonary vascular resistance (PVR). Patients were inhaling 14 to 17 µg iloprost within 15 min and the hemodynamic variables were measured at the indicated time points. Changes in PVR (percent) are shown as median and upper 95% confidence limits of the median. Asterisk indicates p < 0.05 vs. baseline.
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