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Nonadherence with angiotensin-converting enzyme inhibitor therapy

A comparison of different ways of measuring it in patients with chronic heart failure

Allan D. Struthers, MD^*, Robert MacFadyen, MD^*, Callum Fraser, PhD, Jess Robson^*, James J. Morton, PhD, Christophe Junot, BSc and Eric Ezan, PhD

^* Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
Directorate of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
CEA Service de Pharmacologie et d’Immunologie, Gif-sur-Yvette, France
Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, UK

View larger version (27K): [in a new window]   Figure 1 Scattergram of serum ACE activity (U/liter) plasma AcSDKP (pmol/ml), urine AcSDKP (nmol/liter), plasma AI (pmol/liter), plasma AII (pmol/liter), and AII/AI ratio during different patterns of adherence with ACEI therapy.