This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Swan, H. Articles by Toivonen, L. Search for Related Content PubMed PubMed Citation Articles by Swan, H. Articles by Toivonen, L.

Arrhythmic disorder mapped to chromosome 1q42–q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts

Heikki Swan, MD^*, Kirsi Piippo, PhD^*, Matti Viitasalo, MD^*, P.äivi Heikkilä, MD, Timo Paavonen, MD, Katariina Kainulainen, MD^*, Juha Kere, MD, Pekka Keto, MD, Kimmo Kontula, MD^* and Lauri Toivonen, MD^*

^* Department of Medicine, Helsinki University Hospital, Helsinki, Finland
Department of Pathology, University of Helsinki, Helsinki, Finland
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Department of Radiology, Helsinki University Hospital, Helsinki, Finland

View larger version (19K): [in a new window]   Figure 1 Pedigrees of Families 1 and 2. The empty circles/squares stand for unaffected women/men and the filled circles/squares for affected women/men. The unaffected men carrying the disease haplotype is marked with an arrow. Individuals included in the linkage study are indicated with circled numbers. SD = sudden death under the age of 35 years.

View larger version (38K): [in a new window]   Figure 2 Left: Sample of the electrocardiogram of a 9-year-old girl during the maximal load of the exercise stress test (leads II, aVF, V2–5). Middle: Electrocardiogram of the same girl during exercise stress test three years later showing multifocal ventricular ectopic beats. Right: Electrocardiogram obtained during an exercise stress test of a 42-year-old woman demonstrating sustained polymorphic ventricular tachycardia (leads V1–6).

View larger version (28K): [in a new window]   Figure 3 Lod scores calculated by GENEHUNTER for chromosome 1. The data are combined from pedigree 1 (38 markers) and pedigree 2 (8 markers). The X-axis shows genetic markers using the correct order and distances. The Y-axis shows the corresponding lod scores. The highest peak is seen for marker D1S2680.

View larger version (20K): [in a new window]   Figure 4 Kaplan-Meier curves for cumulative survival (continuous line) and cardiac event-free survival (dotted line) among the affected individuals.