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Evidence for the delayed effect in human ischemic preconditioning

Prospective multicenter study for preconditioning in acute myocardial infarction

Toshiyuki Noda, MD^*, Shinya Minatoguchi, MD^*, Kenshi Fujii, MD^a, Masatsugu Hori, MD, Takayuki Ito, MD, Katsuo Kanmatsuse, MD, Masunori Matsuzaki, MD^||, Tetsuji Miura, MD^¶, Hiroshi Nonogi, MD^#, Michihiko Tada, MD, Masaru Tanaka, MD^** and Hisayoshi Fujiwara, MD^*

^a Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
^* Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
The First Department of Medicine, Osaka University School of Medicine, Osaka, Japan
The Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan
^|| The Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan
^¶ The Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
^# Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
^** The Third Department of Internal Medicine, Kyoto University, Kyoto, Japan

View larger version (13K): [in a new window]   Figure 1 Comparison of the increase in the RWMI between the PA(+) group and the PA(–) group. The increase in the RWMI was significantly larger in patients with PA (PA[+] group) than in patients without PA (PA[–] group). PA = preinfarction angina; RWMI = regional wall motion index.

View larger version (14K): [in a new window]   Figure 2 Relationship between the increase in the LVEF and the interval from the first or last PA attack to the onset of acute myocardial infarction. The increase in the LVEF in patients with PA was positively correlated with the interval from the first PA attack to the onset of acute myocardial infarction. LVEF = left ventricular ejection fraction; PA = preinfarction angina.

View larger version (13K): [in a new window]   Figure 3 Relationship between the increase in the RWMI and the interval from the first or last PA attack to the onset of AMI. The increase in the RWMI in patients with PA was positively correlated with the interval from the first PA attack to the onset of AMI. AMI = acute myocardial infarction; PA = preinfarction angina; RWMI = regional wall motion index.