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Measurement of heart rate variability: a clinical tool or a research toy?

Heikki V. Huikuri, MD, FESC, FACC^* , Timo Mäkikallio, MD^* , K. E. Juhani Airaksinen, FESC^*, Raul Mitrani, MD, FACC, Agustin Castellanos, MD, FACC and Robert J. Myerburg, MD, FACC

^* Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
University of Miami School of Medicine, Miami, Florida, USA

View larger version (14K): [in a new window]   Figure 1 The annual number of publications dealing with HRV during the last decade based on search from the MEDLINE system using the key word "heart rate variability." HRV = heart rate variability.

View larger version (16K): [in a new window]   Figure 2 Kaplan-Meier survival curves for the patients with the short-term fractal-like scaling exponent (1) <0.85 or 0.85 and for the patients with the standard deviation of all N-N intervals (SDNN) <70 ms or >70 ms included in the placebo arm of the TRACE study. Short-term scaling exponent was a better predictor of mortality than standard deviation of all N-N intervals in these postinfarction patients. Modified from "Fractal Analysis of Heart Rate Dynamics as a Predictor of Mortality in Patients With Depressed Left Ventricular Function After Acute Myocardial Infarction." (18) with permission. SDNN = standard deviation of N-N intervals.