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Slowed glycogen utilization enhances exercise endurance in patients with heart failure

Donna Mancini, MD^*, Ainat Benaminovitz, MD^*, Marie Elena Cordisco, MS, RN^*, Wahida Karmally, MS, RD^* and Alan Weinberg, PhD

^* Division of Circulatory Physiology, Columbia Presbyterian Medical Center, New York, New York, USA
Department of Surgery, Columbia Presbyterian Medical Center, New York, New York, USA

View larger version (22K): [in a new window]   Figure 1 Glycogen metabolism in muscle; asterisk denotes rate-limiting enzyme.

View larger version (25K): [in a new window]   Figure 2 Histogram of basal respiratory quotients in normal and CHF subjects with a normal diet, following carbohydrate-poor and -rich diets.

View larger version (25K): [in a new window]   Figure 3 Peak VO2 in the normal and CHF groups in the basal, glycogen-depleted, and slowed glycogen-utilization states.

View larger version (31K): [in a new window]   Figure 4 (A) Exercise duration during submaximal exercise in normal and CHF groups. (B) Number of completed cycles during supramaximal exercise in the normal and CHF groups.