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Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction

Results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) Trial

Kenneth W. Mahaffey, MD, FACC^{a* || ¶ #}, Joseph A. Puma, DO^{a* || ¶ #}, N. Alejandro Barbagelata, MD^*, Marcelo F. DiCarli, MD, Massoud A. Leesar, MD, Kevin F. Browne, MD, Paul R. Eisenberg, MD^||, Roberto Bolli, MD, A. Cecilia Casas, MS^{a* || ¶ #}, Victor Molina-Viamonte, MD^¶, Cesare Orlandi, MD^¶, Roger Blevins, PharmD^¶, Raymond J. Gibbons, MD, FACC^#, Robert M. Califf, MD, FACC^{a* || ¶ #}, Christopher B. Granger, MD, FACC^{a* || ¶ #} for the AMISTAD Investigators

^a Duke Clinical Research Institute, Durham, North Carolina, USA
^* Favaloro Foundation, Buenos Aires, Argentina
Harper Hospital, Detroit, Michigan, USA
University of Louisville, Louisville, Kentucky, USA
The Watson Clinic, Lakeland, Florida, USA
^|| Washington University, St. Louis, Missouri, USA
^¶ Medco Research, Inc., Research Triangle Park, North Carolina, USA
^# The Mayo Clinic, Rochester, Minnesota, USA

View larger version (13K): [in a new window]   Figure 1 Stratification and randomization scheme showing the number of patients in each treatment arm and number of patients with determination of final infarct size.

View larger version (19K): [in a new window]   Figure 2 Box-and-whisker plots of the final infarct size as a percentage of the left ventricle by treatment group and infarct location. The boxes represent the 25th and 75th interquartile ranges; vertical lines represent the 5th and 95th percentiles. The median values are shown above the horizontal lines.

View larger version (19K): [in a new window]   Figure 3 Myocardial salvage index = (myocardium at risk – final infarct size)/(final infarct size). See Figure 2 for description of box-and-whisker plots.