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Long-term endothelial dysfunction after coronary artery stenting

^a Bayer Inc., Cardiovascular Clinical Research Laboratory, Toronto, Canada
^b Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada

View larger version (12K): [in a new window]   Figure 1 Percent change in mean luminal diameter of the left anterior descending coronary artery (A) and circumflex artery (B) from baseline, in response to intracoronary acetylcholine infusion. *p = 0.02 versus balloon angioplasty and directional atherectomy groups. Open triangle = Stent group. Closed circle = Balloon angioplasty group. Open square = Directional atherectomy group.

View larger version (106K): [in a new window]   Figure 2 Representative coronary angiograms from patients previously treated with coronary stenting (A), balloon angioplasty (B), and directional atherectomy (C) in the control state (Control) and after acetylcholine 10–4 molar infusion (Ach 10–4). Arrows indicate the intervened left anterior descending artery.

View larger version (22K): [in a new window]   Figure 3 Mean luminal diameter of the left anterior descending coronary artery at baseline (C) and in response to maximal intracoronary acetylcholine infusion (Ach) for all the study patients. BA = balloon angioplasty group; DCA = directional coronary atherectomy group; Stent = stent group. *p = 0.02 versus balloon angioplasty and directional atherectomy groups.