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Endothelial and metabolic characteristics of patients with angina and angiographically normal coronary arteries

Comparison with subjects with insulin resistance syndrome and normal controls

PierMarco Piatti, MD^*, Gabriele Fragasso, MD, Lucilla D. Monti, MD, Andrea Caumo, Chuong Van Phan, Giampietro Valsecchi, PhD, Sabrina Costa, Elena Fochesato, MD^*, Guido Pozza, MD, Antonio E. Pontiroli, MD^* and Sergio Chierchia, MD, FESC, FACC

^* Unita’ di Malattie Metaboliche, Cattedra di Medicina Interna, Divisione di Medicina, Milano, Italy
Cattedra di Clinica Medica Generale e Terapia Medica, Università Vita-Salute, Milano, Italy
Divisione di Statistica e Epidemiologia, Milano, Italy
Divisione di Cardiologia, IRCCS H. San Raffaele, Milano, Italy

View larger version (25K): [in a new window]   Figure 1 ET-1, NOx, systolic and diastolic blood pressure and forearm blood flow levels after an intravenous administration of 0.1 U/kg of insulin in 13 CSX patients (circles), in 9 MSX subjects (triangles) and in 13 normal controls (squares). Histograms represent AUCs for the different parameters in CSX patients (filled bars), in MSX subjects (hatched bars) and in normal controls (open bars). Data are means ± SE. Blood Press. = blood pressure; ET-1 = endothelin-1; F. Blood Flow = forearm blood flow; NOx = nitrite/nitrate. #p < 0.05 vs. basal; *p < 0.05 vs. normal controls; p < 0.01 vs. normal controls; p < 0.05 vs. CSX patients.

View larger version (32K): [in a new window]   Figure 2 GIR FGU and forearm glucose metabolism after an intravenous administration of 0.1 U/kg of insulin in 13 CSX patients (circles), in 9 MSX subjects (squares) and in 13 normal controls (triangles). Histograms represent AUCs for the different parameters in CSX patients (filled bars), in MSX subjects (hatched bars) and in normal controls (open bars). Date are means ± SE. GIR = glucose infusion rate; FGU = forearm glucose uptake; FGOx = forearm glucose oxidation. *p < 0.05 vs. normal controls; p < 0.05 vs. CSX patients.

View larger version (22K): [in a new window]   Figure 3 Relationship between the AUCs of GIR and the AUCs of NOx levels in 13 CSX patients (circles), in 9 MSX subjects (triangles) and in 13 normal controls (squares). Nox = nitrite/nitrate; GIR = glucose infusion rate.