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Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling

Stephanie Hügel, MD^*, Martin Reincke, MD^*, Hinrik Strömer, MD^*, Johannes Winning, MD^*, Michael Horn, PhD^*, Charlotte Dienesch^*, Patricia Mora^*, Harald H. H. W. Schmidt, MD, Bruno Allolio, MD^* and Stefan Neubauer, MD^*

^* Medizinische Universitätsklinik, Würzburg, Germany
Institut für Pharmakologie und Toxikologie, Universität Würzburg, Würzburg, Germany

View larger version (93K): [in a new window]   Figure 1 Representative M-mode tracings of the short-axis LV in a non-OVX + Sham (a), a non-OVX + MI (b), an OVX + MI (c) and an OVX + E2 + MI rat (d) eight weeks after left coronary artery ligation. There is increased LV cavity dimension, akinesis and thinning of anterior wall in all rats with MI.

View larger version (24K): [in a new window]   Figure 2 Left ventricular developed pressure-volume curves for all experimental groups; *p < 0.017 sham versus corresponding MI. A right and downward shift of the curve was observed for all MI groups. (Open circles) Non-OVX + Sham, (filled circles) non-OVX + MI, (open triangles) OVX + Sham, (filled triangles) OVX + MI, (open squares) OVX + E2 + Sham, (filled squares) OVX + E2 + MI.