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Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction

^a Deutsches Herzzentrum and 1. Medizinische Klinik der Technischen Universität München, Munich, Germany

View larger version (24K): [in a new window]   Figure 1 Percentage of monocytes with GP Ib fluorescence signal (left panel) and GP Ib fluorescence intensity (arbitrary units) (right panel) of GP Ib-positive monocytes in whole blood at baseline (control) and after stimulation in vitro with 20 µmol/L ADP in the presence or absence of blocking anti-P-selectin mAbs or of abciximab. *p < 0.01 for the comparison to ADP-stimulated whole blood without mAbs. GP = glycoprotein; mAbs = monoclonal antibodies.

View larger version (145K): [in a new window]   Figure 2 Confocal laser microscopic images (upper panels) and corresponding P-selectin fluorescence images (lower panels) of platelet-leukocyte aggregates after in vitro stimulation of whole blood with 20 µmol/L ADP in the presence or absence of abciximab.

View larger version (41K): [in a new window]   Figure 3 Mac-1 fluorescence intensity of leukocytes with platelets attached (GP Ib +) of platelet-negative leukocytes (GP Ib –) in the monocyte population and in the entire population of myeloid leukocytes (All). GP = glycoprotein.

View larger version (14K): [in a new window]   Figure 4 Overall GP Ib fluorescence intensity (arbitrary units) of monocytes in patients assigned to heparin treatment (closed circles) and in patients assigned to abciximab (open circles). Circles represent median and error bars interquartile range. *p < 0.002 for the comparison between groups. p Values for the comparison with the initial value in each treatment group are given at the bottom and at the top of the graphs. GP = glycoprotein.

View larger version (14K): [in a new window]   Figure 5 Mac-1 fluorescence intensity (arbitrary units) of monocytes in patients assigned to heparin treatment (closed circles) and in patients assigned to abciximab (open circles). Circles represent median and error bars interquartile range. *p < 0.004 for the comparison between groups. p Values for the comparison with the initial value in each treatment group are given at the bottom and at the top of the graph.