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The influence of low afterload on the nature of the stress-velocity relationship

Daniël De Wolf, MD, PhD, Luc Foubert, MD^*, Yves Van Belleghem, MD, Kathy Mareels, MD^*, Dirk Matthys, MD, PhD^a, Henri Verhaaren, MD, PhD, FACC^a and Guido Van Nooten, MD, PhD

^a Department of Pediatrics, Division of Pediatric Cardiology, University Hospital UZGhent, Ghent, Belgium
^* Department of Anesthesia, Division of Cardiac Anesthesia, University Hospital UZGhent, Ghent, Belgium
Department of Surgery, Division of Cardiac Surgery, University Hospital UZGhent, Ghent, Belgium

View larger version (17K): [in a new window]   Figure 1 Regression lines of the relation between end-systolic meridional wall stress (ESWS) and velocity of circumferential fiber shortening (VcFc) at different levels of afterload manipulation for nonvagotomized piglets, vagotomized piglets and vagotomized pigs, showing a comparable curve.

View larger version (8K): [in a new window]   Figure 2 Regression line of the relation between end-systolic wall stress and velocity of circumferential fiber shortening (VcFc) for vagotomized adult pigs after afterload manipulation from baseline to a sodium nitroprusside infusion rate up to 5 µg/kg/min. This relation seems linear, but represents merely a segment of the nonlinear curve as found in Figure 1, in which values at lower afterload obtained during infusion of sodium nitroprusside at a rate of 10 µg/kg/min are included.