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The effects of chronic prostacyclin therapy on cardiac output and symptoms in primary pulmonary hypertension

^a Department of Medicine, Section of Cardiology, Rush University Medical College, Chicago, Illinois, USA

View larger version (30K): [in a new window]   Figure 1 The effects of prostacyclin on (A) pulmonary artery pressure, (B) cardiac output, and (C) pulmonary vascular resistance are shown at baseline, after chronic treatment, and after the dose was reduced. Although prostacyclin chronically lowered the pulmonary artery pressure and raised the cardiac output, acutely reducing the prostacyclin dose affected only the cardiac output. *p < 0.001 vs. baseline; **p < 0.002 vs. baseline; p < 0.001 vs. prostacyclin.