Progression of mitral regurgitation
A prospective Doppler echocardiographic study
Maurice Enriquez-Sarano, MD, FACC*,
Arsene-Joseph Basmadjian, MD*,
Andrea Rossi, MD*,
Kent R. Bailey, PhD ,
James B. Seward, MD, FACC* and
A. Jamil Tajik, MD, FACC*
* Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
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Figure 1 Regurgitant volume (RVol), regurgitant fraction (RF) and effective orifice area (ERO) measured at baseline (B) and at late (L) quantitative echocardiography.
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Figure 2 Progression of mitral regurgitation expressed per year in the overall series and in groups of patients with restricted motion (RM), stable mitral valve prolapse (MVP-S) and new flail leaflet (NF). (Top) Regurgitant volume (RVol) change. The mean rates (95% CI) were 7.4 ml/year (5.1, 9.7), 0.9 ml/year (–1.9, 3.7), 5.9 ml/year (3.4, 8.5), 18.4 ml/year (13.8, 23.0), respectively (p = 0.0002 for group differences). (Middle) Regurgitant fraction (RF) change. The mean rates (95% CI) were 2.9% (1.9, 3.9), 0.8%/year (–0.9, 2.6), 2.1%/year (1.0, 3.4), 7.3%/year (5.0, 9.6), respectively (p = 0.0013 for group differences). (Bottom)Effective regurgitant orifice (ERO) change. The mean rates (95% CI) were 5.9 mm2/year (3.9, 7.8), 0.05 mm2/year (–1.7 to 1.8), 6.2 mm2/year (3.8 to 8.7), 10.6 mm2/year (8.1 to 13.0), respectively (p = 0.0002 for group differences).
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Figure 3 Correlation between change in mitral annulus diameter and change in regurgitant volume. Solid line = regression line.
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