Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure
Evidence of impaired reactivity to nitroglycerin
Manolis Vavuranakis, MD, FACCa,
Christodoulos Stefanadis, MD, FACC, FESCa,
Eleni Triandaphyllidi, MDa,
Konstantinos Toutouzas, MDa and
Pavlos Toutouzas, MD, FACC, FESCa
a Department of Cardiology, Hipprokration Hospital, University of Athens, Athens, Greece
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Figure 1 In vitro and in vivo presentation of the way the pressure wire was used as a guide wire for the ultrasound catheter. On both pictures, top arrow indicates the position of the transducer on the ultrasound catheter and bottom arrow indicates the pressure sensor on the pressure wire.
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Figure 2 Top: Measurements of CSLA at end diastole and end systole during the same cardiac cycle are displayed. Electrocardiogram is shown at the bottom of the screen after the on-off signal. Bottom: Electrocardiogram and P1 (through the guiding catheter) with simultaneous P2 (obtained by the pressure wire) are displayed on the strip chart of the Electronics for medicine DR-12 system, after the on-off signal. CSLA = cross-sectional lumen area; ECG = electrocardiogram; P1 = aortic pressure; P2 = intracoronary pressure.
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Figure 3 Cross-sectional plaque area is plotted against the change that occurred in C-DIST after IC-NTG in nondiabetics. A good inverse correlation is observed (r2 = 0.746, p = 0.0001). C-DIST = coronary artery distensibility; IC-NTG = intracoronary nitroglycerin.
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Figure 4 Cross-sectional plaque area is plotted against the change that occurred in C-DIST after IC-NTG in diabetics. There is no good correlation between these two variables (r2 = 0.19, p = 0.06). Abbreviations as in Figure 3.
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