Clinical profiles of four large pedigrees with familial dilated cardiomyopathy
Preliminary recommendations for clinical practice
Kathy A. Crispell, MDa,
Anita Wray, MDa,
Hanyu Ni, PhD, MPHa,
Deirdre J. Nauman, RN, BSNa and
Ray E. Hershberger, MD, FACCa
a Heart Failure Treatment Program, Division of Cardiology, Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
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Figure 1 Pedigree of OSHU FDC-1. OHSU FDC-1 is a white family comprised of 165 relatives. It has seven generations (circa 1850 to 1995). The family has a wide geographic distribution ranging from Alaska and the western U.S. to the Midwest and southern U.S.
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Figure 2 Pedigree of OHSU FDC-2. OHSU FDC-2 is comprised of two Caucasian families spanning five generations that includes 20 paternal (A) and 84 maternal (B) relatives. The index patient’s paternal grandmother (III-A) died from dilated cardiomyopathy at the age of 51 years. The geographic distribution of these families range from the Pacific Northwest to the Midwest and southern U.S. The number 19 below the subject symbol and the number in parentheses (#4) denote the number of known descendants and the number of screened subjects, respectively, not shown due to space limitations.
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Figure 3 Pedigree of OHSU FDC-3. FDC-3 is a very large African-American family spanning eight generations with 481 living relatives who are related to the index patient by her maternal grandfather. All members of generations I and II are deceased and only four members of generation III are living. FDC-3 has a broad geographic distribution with most of the family residing in the midwestern and southern U.S., and a small portion reside in the Pacific Northwest. Numbers below the subject symbols and numbers in parentheses, i.e. (#10), denote the number of known descendants and the number of screened subjects, respectively, not shown due to space limitations.
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Figure 4 Pedigree of OHSU FDC-4. OHSU FDC-4 is a white pedigree that is comprised of 55 relatives from four living generations. Family members are located in the Pacific Northwest, the Southwest and the East Coast.
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Figure 5 Cumulative rate of FDC by age group.
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