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The deletion genotype of the angiotensin I-converting enzyme is associated with an increased vascular reactivity in vivo and in vitro

Daniel Henrion, PhD^a, Joelle Benessiano, PhD^*, Ivan Philip, MD^#, Sandrine Vuillaumier-Barrot, PhD^*, Marc Iglarz, BSc^*, Gaetan Plantefève, MD^#, Didier Chatel, MD, Ulrich Hvass, MD, Geneviève Durand, PhD^*, Jean-Marie Desmonts, MD^#, Philippe Amouyel, MD^** and Bernard I. Lévy, MD, PhD^a

^a Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR Circulation, Université Paris VII, Hôpital Lariboisière, Paris, France
^* Laboratoire de Biochimie, Hôpital Xavier Bichat, Paris, France
^# Service d’Anesthésie-Réanimation, Hôpital Xavier Bichat, Paris, France
Service de Chirurgie Cardiaque, Hôpital Xavier Bichat, Paris, France
^** Service d’Epidémiologie et de Santé Publique, Institut Pasteur, Lille, France

View larger version (23K): [in a new window]   Figure 1 Typical recording obtained from two segments of a human internal mammary artery. Several concentration-response curves for phenylephrine (PE) were conducted at 60-min intervals. Upper panel: Angiotensin II was added to the bath of the artery 10 min before the last concentration-response curves for PE. Lower panel: The solvent only (physiologic salt solution) was added. The potentiating effect of angiotensin II was calculated by comparing the second concentration-response curve (2) with the first (1). W = washout.

View larger version (23K): [in a new window]   Figure 2 Dose-response curves for phenylephrine in the process of an extracorporeal circulation in patients with DD genotype (n = 15 patients, excepted for phenylephrine 150 µg: n = 13) or the II/ID genotypes (n = 30, excepted for phenylephrine 150 µg: n = 24). Mean value ± SEM is represented. *p < 0.03, two-factor ANOVA for repeated measures.

View larger version (28K): [in a new window]   Figure 3 Effect of the DD and II/ID genotypes on concentration-response curves for phenylephrine in the presence of angiotensin II (ANG II, 10 pmol/liter) or the solvent (CONTROL). Arterial segments were obtained from patients with DD genotype (n = 12) or the II/ID genotypes (n = 24) of the angiotensin I-converting enzyme. Mean value ± SEM is given. *p < 0.0001, two-factor ANOVA for repeated measures, ANG II vs. CONTROL. #p < 0.003, two-factor ANOVA for repeated measures, genotype DD vs. genotypes II/ID.