Arterial remodeling in the left coronary system1
The role of high-density lipoprotein cholesterol
Allen J. Taylor, MD, FACC*,
Allen P. Burke, MD ,
Andrew Farb, MD, FACC,
Pouya Yousefi,
Gray T. Malcom, PhD ,
John Smialek, MD and
Renu Virmani, MD, FACC
* Department of Hematology and Vascular Biology, Walter Reed Army Institute of Research, Washington, DC, USA
Louisiana State University, New Orleans, Louisiana, USA
University of Maryland, Baltimore, Maryland, USA
Cardiovascular Division, Armed Forces Institute of Pathology, Washington, DC, USA
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Figure 1 Schematic representation of the methods used to classify different types of arterial remodeling. Definitions as described in "Methods."
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Figure 2 Mean IEL area (mm2) for sections with plaque area <1 mm2 (open bars) and  1 mm2 (black bars) for serial LAD sections, proximal to distal (ANOVA p < 0.0001). At all sites, IEL area was smaller in sections with minimal plaque.
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Figure 3 Mean plaque area (mm2) for sections with compensatory, neutral and negative remodeling (ANOVA p < 0.0001) (mean ± standard error).
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Figure 4 Mean HDL cholesterol values associated with different types of arterial remodeling including compensatory (open bar), neutral (hatched bar) and negative (black bar) subtypes (ANOVA p = 0.019) (mean ± standard deviation).
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Figure 5 Relationship between the remodeling score and HDL cholesterol for cases with advanced (AHA grade 5) atherosclerosis. A higher remodeling score indicates a greater frequency of sections displaying negative remodeling (r2 = 0.37; p = 0.025).
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