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Myoglobin, creatine-kinase-MB and cardiac troponin-I 60-minute ratios predict infarct-related artery patency after thrombolysis for acute myocardial infarction

Results from the thrombolysis in myocardial infarction study (TIMI) 10B

Milenko J. Tanasijevic, MD^*,1, Christopher P. Cannon, MD, Elliott M. Antman, MD, Donald R. Wybenga, MD^*, George A. Fischer, PhD^*, Christine Grudzien^*, C. Michael Gibson, MD, James W. Winkelman, MD^*, Eugene Braunwald, MD for the TIMI 10B Investigators

^* Clinical Laboratories, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Department of Medicine, VA Medical Center, West Roxbury, Massachusetts, USA

View larger version (40K): [in a new window]   Figure 1 ROC curves of the 60-min value (top), 60-min ratio (middle) and 60-min slope (bottom) of myoglobin, CK-MB and cardiac Troponin-I (cTnI), for noninvasive prediction of occlusion after thrombolysis.

View larger version (12K): [in a new window]   Figure 2 Probability of IRA patency according to the myoglobin 60-min ratio. The probability of patency corresponds to the myoglobin 60-min ratio values greater than or equal to the specific cutpoints.