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Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability

^a Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

View larger version (22K): [in a new window]   Figure 1 Protocol design. IA = intra-arterially; IV = intravenously; D5W = 5% dextrose.

View larger version (17K): [in a new window]   Figure 2 Effects of acetylcholine on femoral blood flow velocity and femoral vascular resistance index, before and after glutathione. Data represent mean ± SEM; p values represent results of two-way analysis of variance.

View larger version (23K): [in a new window]   Figure 3 Effects of acetylcholine on flow velocity and femoral vascular resistance index in patients with normal (left) and depressed (right) endothelial function, before and after glutathione. Data represent mean ± SEM; p values represent results of two-way analysis of variance.

View larger version (16K): [in a new window]   Figure 4 Effects of nitroglycerin (NTG) and sodium nitroprusside on femoral blood flow velocity and femoral vascular resistance index, before and after glutathione. Data represent mean ± SEM.