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Elevated endothelin concentrations are associated with reduced coronary vasomotor responses in patients with chest pain and normal coronary arteriograms

Ian D. Cox, MRCP^*, Hans E. Bøtker, MD, Jens P. Bagger, MD, Helle S. Sonne, MD, Bent Ø Kristensen, MD and Juan Carlos Kaski, MD, FACC^*

^* Department of Cardiological Sciences, St. George’s Hospital Medical School, London, United Kingdom
Department of Cardiology, Skejby University Hospital, Aarhus, Denmark
Department of Cardiology, Hammersmith Hospital, London, United Kingdom

View larger version (22K): [in a new window]   Figure 1 Scattergram illustrating the relationship between baseline arterial endothelin (ET) concentration and percentage fall in coronary vascular resistance during rapid atrial pacing in men and women; dashed lines represent simple regression plots for women (circles) (R2 = 0.34; p = 0.06) and men (squares) (R2 = 0.62; p = 0.11).