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Exaggerated QT prolongation after cardioversion of atrial fibrillation

^a Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
^b Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

View larger version (21K): [in a new window]   Figure 1 Precordial QT (top), heart rate (middle) and plasma dofetilide (bottom) during dofetilide infusion in atrial fibrillation or flutter and after cardioversion to normal sinus rhythm (SR). Group I patients are those in whom the SR infusion was stopped prematurely for excess QT prolongation. Group II patients received the whole dofetilide infusion in SR. *p < 0.01 vs baseline.