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Survival 12 years after randomization to streptokinase: the influence of thrombolysis in myocardial infarction flow at three to four weeks

^a Cardiovascular Research Unit, Cardiology Department, Green Lane Hospital, Auckland, New Zealand

View larger version (13K): [in a new window]   Figure 1 Late actuarial survival after randomization to receive streptokinase or placebo after myocardial infarction. The log-rank comparison between the streptokinase and placebo groups was p = 0.022. At 5 years survival was 84% (95% confidence interval [CI] 76 to 90) in the streptokinase group and 70% (95% CI 60 to 77) in the placebo group (p = 0.023). At 12 years, survival was 66% (95% CI 55 to 75) in the streptokinase group and 51% (95% CI 41 to 60) in the placebo group (p = 0.022).

View larger version (18K): [in a new window]   Figure 2 Late survival after myocardial infarction according to the Thrombolysis in Myocardial Infarction (TIMI) flow grade at 3 to 4 weeks. (A) The log-rank three-way comparisons between TIMI 3, 2 and 0–1 flow, truncated at 1, 5 and 12 years, were p = 0.005, 0.005 and 0.028, respectively. The log-rank two-way comparisons of TIMI 3 versus TIMI 2 flow at 1, 5, and 12 years were p = 0.047, 0.045 and 0.36, respectively. The log-rank two-way comparisons of TIMI 3 versus TIMI 0–1 flow, truncated at 1, 5 and 12 years, were p = 0.001, 0.0009 and 0.006, respectively. The log-rank two-way comparisons of TIMI 0–1 versus TIMI 2 flow, truncated at 1, 5 and 12 years, were p = 0.22, 0.25 and 0.15, respectively. (B) Survival adjusted for the ejection fraction and exercise duration; the log-rank comparisons, truncated at 5 and 12 years, were p = 0.026 and 0.27, respectively.