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Effects of folate supplementation in hyperhomocysteinemic pigs

Pierre Ambrosi, MD^*, Pierre H. Rolland, PhD, Heidi Bodard, PhD, André Barlatier, PhD, Philippe Charpiot, PhD, Gwladys Guisgand, BSc, Alain Friggi, PhD, Odette Ghiringhelli, BSc, Gilbert Habib, MD^*, Gilles Bouvenot, MD, Danielle Garçon, PhD and Roger Luccioni, MD, FACC^*

^* Department of Cardiology, Hôpital de la Timone, Marseille, France
INSERM CJF 94-01, Marseille, France
Laboratory of Biochemistry, Faculté de Pharmacie, Marseille, France
Laboratory of Therapeutics, Faculté de Médecine, Marseille, France

View larger version (146K): [in a new window]   Figure 1 Photomicrographs of renal (A,a) and iliac (B,b) arteries of pigs fed the control (small letters) or the methionine-rich diet (capitals). The transverse sections (black letters) were obtained at x150 after orcein staining. They show elastic lamina fragmentation (black arrow) and cellular hyperplasia (black arrowheads) in the media. The views of the luminal surface of the endothelium (white letters) were obtained with scanning electron microscopy at x750. Endothelial cell bulging in the arterial lumen is associated with intercellular holes (white arrows).