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Alterations in cardiac sarcoplasmic reticulum Ca²⁺ regulatory proteins in the atrial tissue of patients with chronic atrial fibrillation

Tomoko Ohkusa, MD, PhD^*, Takeshi Ueyama, MD, PhD^*, Jutaro Yamada, MD^*, Masafumi Yano, MD, PhD^*, Yoshihiko Fujumura, MD, PhD, Kensuke Esato, MD, PhD and Masunori Matsuzaki, MD, PhD, FACC^*

^* Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, 755-8505, Japan
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, 755-8505, Japan

View larger version (19K): [in a new window]   Figure 1 Characteristics of [3H]ryanodine binding to atrial tissue in patients with either atrial fibrillation (AF) or normal sinus rhythm (NSR). In patients with AF, there was a significant depression in the maximum number of binding sites (Bmax) in each atrium (by comparison with the value for the right atrium in patients with NSR). The dissociation constant (Kd) did not differ significantly among the three groups. R, right atrium; L, left atrium. Data are mean ± SD.

View larger version (15K): [in a new window]   Figure 2 Relation between the maximum number of [3H]ryanodine binding sites (Bmax) in the atrium of patients with atrial fibrillation (AF) and magnitude of pulmonary capillary wedge pressure (PCWP) (i), mean pulmonary arterial pressure (mPAP) (ii), and right atrial pressure (RAP) (iii). The Bmax for RyR was smaller at higher levels of PCWP. There was no significant difference between the Bmax values obtained for the two levels of mPAP or the two levels of RAP. Data are mean ± SD.

View larger version (28K): [in a new window]   Figure 3 Expression levels of the mRNAs encoding cardiac RyR (A) and Ca2+-ATPase (B) in the atrial tissue of patients with either atrial fibrillation (AF) or normal sinus rhythm (NSR), and representative data showing the levels of the two mRNAs. In patients with AF, there was a significant depression in the expression levels of RyR mRNA (A) and Ca2+-ATPase mRNA (B) in each atrium (by comparison with the levels in the right atrium of patients with NSR). R, right atrium; L, left atrium. Data are mean ± SD.

View larger version (30K): [in a new window]   Figure 4 Relation between the expression level of RyR mRNA (A) or Ca2+-ATPase mRNA (B) in the atrium of patients with atrial fibrillation (AF) and magnitude of pulmonary capillary wedge pressure (PCWP) (A-i, B-i), mean pulmonary arterial pressure (mPAP) (A-ii, B-ii), and right atrial pressure (RAP) (A-iii, B-iii). Data are mean ± SD.