Effect of acetylsalicylate on cardiac and muscular pain induced by intracoronary and intra-arterial infusion of bradykinin in humans
Achille Gaspardone, MD, MPhil, FACCa,
Filippo Crea, MD, FACCa,
Fabrizio Tomai, MD, FACCa,
Francesco Versaci, MD, FACCa,
Antonio Pellegrino, MDa,
Luigi Chiariello, MD, FACCa and
Pier A. Gioffré, MDa
a Divisione di Cardiochirurgia, Università di Roma Tor Vergata, Rome, Italy.
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Figure 1 Diagrammatic representation of the infusion protocol for intra-iliac study. After randomization, BK or adenosine was infused at increasing doses for periods of 2 min each. At the onset of pain, either BK or adenosine infusion was continued to complete the infusion protocol and was then stopped. Ten minutes after the disappearance of BK or adenosine-induced pain, the cross-over infusion with adenosine or BK was carried out. At the end of the first phase of the infusion protocol, acetylsalicylate was infused intravenously. Thirty minutes after the end of acetylsalicylate infusion a second randomization was performed, and the same infusion protocol with BK or adenosine was repeated.
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Figure 2 Maximal pain severity (median values and interquartile ranges) and time to pain onset (mean values ± SD) during the intra-iliac infusion of BK (squares) and adenosine (circles), before and after acetylsalicylate administration. The maximal duration of the infusion was 750 s.
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Figure 3 Effect of increasing doses of BK or adenosine on the resistance index before (Panel A) and after acetylsalicylate administration (Panel B). Data are mean ± SD. Differences between groups (BK and adenosine) before and after acetylsalicylate administration at the different steps were not significant. *p < 0.001 compared with baseline values.
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Figure 4 Maximal pain severity (median values and interquartile ranges) and time to pain onset (mean values ± SD) during intracoronary infusion of BK, before and after acetylsalicylate administration. The maximal duration of the infusion was 750 s.
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