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Intensive Glycemic Control and the Prevention of Cardiovascular Events: Expert Consensus Document

2009 Appropriateness Criteria for Coronary Revascularization
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J Am Coll Cardiol, 1999; 34:146-154
© 1999 by the American College of Cardiology Foundation
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Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery

Hiroaki Kawano, MDa, Takeshi Motoyama, MDa, Osamu Hirashima, MDa, Nobutaka Hirai, MDa, Yuji Miyao, MDa, Tomohiro Sakamoto, MDa, Kiyotaka Kugiyama, MDa, Hisao Ogawa, MDa and Hirofumi Yasue, MDa

a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan



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  		Figure 1 Effects of oral glucose loading on the flow-mediated dilation (FMD) of the brachial artery. There was a significant difference in FMD among the three groups (p < 0.01, by ANOVA). DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance. Data are expressed as mean ± SE. *p < 0.01, versus fasting; **p < 0.005, versus fasting; {dagger}p < 0.01, versus 1 h.

 


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  		Figure 2 Comparison of the flow-mediated dilation of the brachial artery in the fasting state, 1 and 2 h after oral glucose loading among the three groups. DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance. Data are expressed as mean ± SE.

 


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  		Figure 3 Effects of oral glucose loading on plasma TBARS levels. There was a significant difference in the plasma TBARS levels among the three groups (p < 0.01 by ANOVA). DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance; TBARS: thiobarbituric acid reactive substances. Data are expressed as mean ± SE. *p < 0.05, versus fasting; **p < 0.01, versus fasting; {dagger}p < 0.05, versus 1 h.

 


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  		Figure 4 Comparison of plasma TBARS levels in the fasting state, 1 and 2 h after oral glucose loading among the three groups. DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance; TBARS: thiobarbituric acid reactive substances. Data are expressed as mean ± SE.

 


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  		Figure 5 Correlation between the flow-mediated dilation of the brachial artery and the plasma glucose levels. There was a significant negative correlation between them.

 


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  		Figure 6 Correlation between the plasma TBARS levels and the plasma glucose levels. There was a significant positive correlation between them. TBARS: thiobarbituric acid reactive substances.

 
 
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