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Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery

^a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

View larger version (15K): [in a new window]   Figure 1 Effects of oral glucose loading on the flow-mediated dilation (FMD) of the brachial artery. There was a significant difference in FMD among the three groups (p < 0.01, by ANOVA). DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance. Data are expressed as mean ± SE. *p < 0.01, versus fasting; **p < 0.005, versus fasting; p < 0.01, versus 1 h.

View larger version (29K): [in a new window]   Figure 2 Comparison of the flow-mediated dilation of the brachial artery in the fasting state, 1 and 2 h after oral glucose loading among the three groups. DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance. Data are expressed as mean ± SE.

View larger version (15K): [in a new window]   Figure 3 Effects of oral glucose loading on plasma TBARS levels. There was a significant difference in the plasma TBARS levels among the three groups (p < 0.01 by ANOVA). DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance; TBARS: thiobarbituric acid reactive substances. Data are expressed as mean ± SE. *p < 0.05, versus fasting; **p < 0.01, versus fasting; p < 0.05, versus 1 h.

View larger version (34K): [in a new window]   Figure 4 Comparison of plasma TBARS levels in the fasting state, 1 and 2 h after oral glucose loading among the three groups. DM: diabetes mellitus; IGT: impaired glucose tolerance; NGT: normal glucose tolerance; TBARS: thiobarbituric acid reactive substances. Data are expressed as mean ± SE.

View larger version (18K): [in a new window]   Figure 5 Correlation between the flow-mediated dilation of the brachial artery and the plasma glucose levels. There was a significant negative correlation between them.

View larger version (18K): [in a new window]   Figure 6 Correlation between the plasma TBARS levels and the plasma glucose levels. There was a significant positive correlation between them. TBARS: thiobarbituric acid reactive substances.