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Effects of naloxone on myocardial ischemic preconditioning in humans

Fabrizio Tomai, MD, FACC^*, Filippo Crea, MD, FACC, Achille Gaspardone, MD, FACC^*, Francesco Versaci, MD, FACC^*, Anna S. Ghini, MD^*, Claudio Ferri, MD, Giovambattista Desideri, MD, Luigi Chiariello, MD, FACC^* and Pier A. Gioffré, MD^*

^* Divisione di Cardiochirurgia, Università di Roma Tor Vergata, European Hospital, Rome, Italy
Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Rome, Italy
Cattedra di Clinica Medica I, Università La Sapienza, Rome, Italy

View larger version (38K): [in a new window]   Figure 1 Values of ST-segment shifts on the intracoronary electrocardiogram (IC-ECG) and of cardiac pain severity at the end of the first and second balloon inflations in the two groups of patients. In naloxone-treated patients, ST-segment changes and cardiac pain severity at the end of the second balloon inflation were similar to those at the end of the first inflation. Conversely, in placebo-treated patients, ST-segment changes and cardiac pain severity at the end of the second balloon inflation were significantly less than those at the end of the first inflation.