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Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study

David S. Sheps, MD, MSPH, FACC^*, Robert P. McMahon, PhD, Kathleen C. Light, PhD, William Maixner, PhD, DDS, Carl J. Pepine, MD, FACC, Jerome D. Cohen, MD, FACC^||, A. David Goldberg, MD^¶, Robert Bonsall, PhD^#, Robert Carney, PhD^#, Peter H. Stone, MD, FACC^**, David Sheffield, PhD^*, Peter G. Kaufmann, PhD the PIMI Investigators

^* East Tennessee State University, Johnson City, Tennessee, USA
Maryland Medical Research Institute, Baltimore, Maryland, USA
University of North Carolina, Chapel Hill, North Carolina, USA
University of Florida, Gainesville, Florida, USA
^|| St. Louis University Medical Center, St. Louis, Missouri, USA
^¶ Henry Ford Hospital, Detroit, Michigan, USA
^# Emory University School of Medicine, Atlanta, Georgia, USA
^** Brigham and Women’s Hospital, Boston, Massachusetts, USA
National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

View larger version (12K): [in a new window]   Figure 1 Kaplan-Meier estimates of percentage of patients with angina by duration of bicycle exercise (minutes) for patients classified by the average of resting hot pain threshold (<41°C vs. 41°C) measures from two days of testing. The solid line refers to patients with hot pain threshold 41°C, and the broken line refers to patients with hot pain threshold <41°C. RR = rate ratio.