Adenosine causes the release of active renin and angiotensin II in the coronary circulation of patients with essential hypertension
Agostino Virdis*,
Lorenzo Ghiadoni*,
Mario Marzilli ,
Enrico Orsini,
Stefania Favilla*,
Piero Duranti*,
Stefano Taddei*,
Paolo Marraccini and
Antonio Salvetti*
* Department of Internal Medicine, University of Pisa, Pisa, Italy
C.N.R. Institute of Clinical Physiology, Pisa, Italy
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Figure 1 Line graphs show arterial (open circles) and venous (solid circles) concentrations of active renin (A.R.) and angiotensin II (Ang II) during intracoronary adenosine infusion in 12 essential hypertensive patients. Data are shown as mean ± SEM. *p < 0.05 or less.
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Figure 2 Bars show net balance of active renin (A.R.) and angiotensin II (Ang II) in 12 essential hypertensive patients. Data are shown as mean ± SEM. *p < 0.05 or less versus basal.
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Figure 3 (A) Line graphs show arterial (open circles) and venous (solid circles) concentrations of active renin (A.R.) in basal conditions (left) and in the presence of benazeprilat infusion (BEN, 25 µg/min, right) in five essential hypertensive patients. Data are shown as mean ± SEM. *p < 0.05 or less. (B) Line graphs show arterial (open circles) and venous (solid circles) concentrations of angiotensin II (Ang II) in basal conditions (left) and in the presence of benazeprilat infusion (right) in five essential hypertensive patients. Data are shown as mean ± SEM. *p < 0.05 or less.
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