Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals
Chen-Huan Chen, MDa,1,
Masaru Nakayama, MD, PhDa,
Maurice Talbot, RNa,
Erez Nevo, MD, DSca,
Barry Fetics, BEa,
Gary Gerstenblith, MDa,
Lewis C. Becker, MDa and
David A. Kass, MDa
a Division of Cardiology, Department of Medicine and Department of Biomedical Engineering, Johns Hopkins University Medical Institutions, Baltimore, Maryland, 21287, USA
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Figure 1 Effects of intravenous verapamil versus 0.5N NaCl on resting cardiovascular hemodynamics. A. Example showing reduction of carotid pulse augmentation index (left panel), increases in left ventricular (LV) volumes (middle) and decline in peak ventricular power (right). Dotted curves are control and solid curves are post verapamil. B. Group data showing effects of verapamil on supine hemodynamics at rest. Open bars show saline data and solid bars verapamil. * = p < 0.05; ** = p < 0.01 between studies. Error bars are SEM.
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Figure 2 Summary hemodynamic data for vascular and ventricular loading between saline and verapamil studies. Open circles denote saline and solid circles verapamil effects. Pre-D and Post-D indicate before and after infusion under supine rest condition. Pre-EX = pre-exercise in upright position; EX1 = stage-1 exercise (25W); EXmax = matched maximal exercise level (100W). There was a consistent increase in end-diastolic volume (EDV) during exercise. The increase in end-systolic volume (ESV), however, diminished during exercise to match saline controls. Arterial load (effective arterial elastance Ea and total peripheral resistance TPR) was lower with verapamil while stroke volume was greater. * = p < 0.05; ** = p < 0.01 between studies. Error bars are SEM.
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