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Abciximab in the treatment of acute myocardial infarction eligible for primary percutaneous transluminal coronary angioplasty

Results of the glycoprotein receptor antagonist patency evaluation (GRAPE) pilot study

Lambert F. M. van den Merkhof, MD^*, Felix Zijlstra, MD, PhD, Hans Olsson, MD, Lars Grip, MD, PhD, Gerrit Veen, MD, PhD^||, Frits W. H. M. Bär, MD, PhD^¶, Marcel J. B. M. van den Brand, MD, PhD^#, Maarten L. Simoons, MD, PhD, FACC^# and Freek W. A. Verheugt, MD, PhD, FACC^*

^* Heartcenter, University Hospital, Nijmegen, The Netherlands
Weezenlanden Hospital, Zwolle, The Netherlands
Örebro Medical Center Hospital, Örebro, Sweden
Sahlgrenska University Hospital, Göteborg, Sweden
^|| Free University Hospital, Amsterdam, The Netherlands
^¶ University Hospital Maastricht, Maastricht, The Netherlands
^# Thoraxcenter, University Hospital, Rotterdam, The Netherlands

View larger version (30K): [in a new window]   Figure 1 Relation between the time interval symptom onset–abciximab and the patency of the infarct-related artery at angiography. Black bars: Thrombolysis in Myocardial Infarction (TIMI) flow grade 2. Gray bars: TIMI flow grade 3.

View larger version (15K): [in a new window]   Figure 2 Preangioplasty Thrombolysis in Myocardial Infarction (TIMI) flow grade 3 (with 95% confidence interval) in the reported emergency room initiated abciximab patency trials, each separately and together, compared with that preangioplasty in the angioplasty arm of the GUSTO-IIb Angioplasty Substudy (17). angio = angiography; GRAPE = Glycoprotein Receptor Antagonist Patency Evaluation; SPEED = Strategies for Patency Enhancement in the Emergency Department study.