Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels
Kiyotaka Kugiyama, MDa,
Takeshi Motoyama, MDa,
Hideki Doi, MDa,
Hiroaki Kawano, MDa,
Nobutaka Hirai, MDa,
Hirofumi Soejima, MDa,
Yuji Miyao, MDa,
Keiji Takazoe, MDa,
Yasushi Moriyama, MDa,
Yuji Mizuno, MDa,
Ryusuke Tsunoda, MDa,
Hisao Ogawa, MDa,
Tomohiro Sakamoto, MDa,
Seigo Sugiyama, MDa and
Hirofumi Yasue, MDa
a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

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Figure 1 Percentage increase in brachial arterial diameter from baseline during reactive hyperemia before and after treatment with alpha-tocopherol (open circles) or placebo (closed circles) in patients with high remnant lipoproteins levels (n = 20 patients in each treatment) and in those with low remnants levels (n = 15 patients in each treatment). Significant effect of alpha-tocopherol treatment was observed in patients with high remnant lipoproteins levels as compared with that of placebo but not in those with low remnants levels (by two-way analysis of variance followed by post hoc testing with Scheffé test).
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