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Improvement in endothelial function by angiotensin-converting enzyme inhibition in non–insulin-dependent diabetes mellitus

Gerard O’Driscoll, MB, BCh, BAO, FRACP^a, Daniel Green, PhD, Andrew Maiorana, MSc, Kim Stanton, MB, BS, FRACP^*, Frances Colreavy, MB, BCh, BAO, FFARCSI^a and Roger Taylor, MB, BS, FRACP

^a Departments of Cardiology and Endocrinology, Royal Perth Hospital, Nedlands, Australia
^* Department of Diabetes, Royal Perth Hospital, Nedlands, Australia
Department of Human Movement, The University of Western Australia, Nedlands, Australia
Department of Medicine, The University of Western Australia, Nedlands, Australia

View larger version (16K): [in a new window]   Figure 1 FBF response to three doses of ACh after placebo (open circles) or enalapril (filled squares) administration for four weeks. FBF is expressed as the percentage change in the ratio of infusion arm to noninfusion arm flows relative to the baseline period preceding the administration of ACh. Values are means ± SE. Vasodilation to ACh was significantly increased (p < 0.02).

View larger version (16K): [in a new window]   Figure 2 FBF response to three doses of SNP after placebo (open circles) or enalapril (filled squares) administration for four weeks. FBF is expressed as the percentage change in the ratio of infusion arm to noninfusion arm flows relative to the baseline period preceding the administration of SNP. Values are means ± SE. The responses to the endothelium-independent vasodilator, SNP, were unchanged by enalapril therapy.

View larger version (15K): [in a new window]   Figure 3 FBF response to three doses of LNMMA after placebo (open circles) or enalapril (filled squares) administration for four weeks. FBF is expressed as the percentage change in the ratio of infusion arm to noninfusion arm flows relative to the baseline. Values are means ± SE. The endothelium, NO-dependent vasoconstrictor responses to LNMMA were significantly augmented by enalapril therapy (p < 0.002).