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Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease

Results from the pilot phase of the Women’s Ischemia Syndrome Evaluation (WISE) Study

Steven E. Reis, MD, FACC^*, Richard Holubkov, PhD^*, Joon S. Lee, MD, FACC^*, Barry Sharaf, MD, FACC, Nathaniel Reichek, MD, FACC, William J. Rogers, MD, FACC, Edward G. Walsh, PhD, Anthon R. Fuisz, MD, Richard Kerensky, MD, FACC^||, Katherine M. Detre, MD, DrPH, FACC^¶, George Sopko, MD^#, Carl J. Pepine, MD, FACC^|| for the WISE Investigators

^* Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Division of Cardiology, Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
Division of Cardiology, Department of Medicine, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania, USA
Division of Cardiology, Department of Medicine, University of Alabama, Birmingham, Alabama, USA
^|| Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida, USA
^¶ Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
^# Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

View larger version (9K): [in a new window]   Figure 1 Relationship between coronary flow velocity reserve (CVR) and volumetric coronary flow reserve (CFR) in women with chest pain in the absence of obstructive coronary artery disease (Pearson correlation = 0.87, p < 0.001).

View larger version (15K): [in a new window]   Figure 2 Sensitivities and specificities of different thresholds of coronary velocity reserve for diagnosing microvascular dysfunction. Solid line = sensitivity; dashed line = specificity.