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The Women’s Ischemia Syndrome Evaluation (WISE) Study: protocol design, methodology and feasibility report

C. Noel Bairey Merz, MD, FACC^* , Sheryl F. Kelsey, PhD, Carl J. Pepine, MD, FACC, Nathaniel Reichek, MD, FACC^||, Steven E. Reis, MD, FACC^¶, William J. Rogers, MD, FACC^#, Barry L. Sharaf, MD, FACC^**, George Sopko, MD for the WISE Study Group

^* Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Department of Medicine, University of California School of Medicine, Los Angeles, California, USA
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida, USA
^|| Division of Cardiology, Department of Medicine, Allegheny General Hospital, MCP-Hahnemann School of Medicine, Pittsburgh, Pennsylvania, USA
^¶ Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
^# Division of Cardiology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
^** Rhode Island Hospital, Providence, Rhode Island, USA
Division of Heart and Vascular Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

View larger version (26K): [in a new window]   Figure 1 Women’s Ischemia Syndrome Evaluation common core testing flow diagram. CV = cardiovascular; ECG = electrocardiography; LV = left ventricular; MR = magnetic resonance; P = phosphorus.

View larger version (22K): [in a new window]   Figure 2 Women’s Ischemia Syndrome Evaluation reproductive hormone status characterization diagram. FSH = follicle-stimulating hormone; HRT = hormone replacement therapy; LH = luteinizing hormone; LMP = last menstrual period; OC = oral contraceptives; PERIMENO = perimenopausal; POSTMENO = postmenopausal; PREMENO = premenopausal. *>3 months before study entry.

View larger version (15K): [in a new window]   Figure 3 Women’s Ischemia Syndrome Evaluation cumulative frequency distribution of coronary artery severity scores.