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A prospective study of fibrinogen and risk of myocardial infarction in the physicians’ health study

Jing Ma, MD, PhD^*, Charles H. Hennekens, MD, DrPH^* , Paul M. Ridker, MD and Meir J. Stampfer, MD, DrPH^{* ||}

^* Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Division of Cardiovascular Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
^|| Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA

View larger version (14K): [in a new window]   Figure 1 Age- and smoking-adjusted relative risk (95% confidence interval) of future myocardial infarction associated with baseline plasma fibrinogen levels in the Physicians’ Health Study. Numbers of cases/control subjects were: 89/99 in the 1st to 50th percentile, 73/80 in the 51st to 90th percentile and 37/20 in the >90th percentile.

View larger version (13K): [in a new window]   Figure 2 Age- and smoking-adjusted relative risk (95% confidence interval) of future myocardial infarction according to fibrinogen levels and aspirin assignment in the Physicians’ Health Study. Numbers of cases/control subjects were: in aspirin group, 50/80 for fibrinogen <343 mg/dl, 15/10 for fibrinogen 343 mg/dl; in placebo group, 112/99 for fibrinogen <343 mg/dl, 22/10 for fibrinogen 343 mg/dl.