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Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia

Andrzej Szczeklik, MD, PhD^a, Jacek Musia, MD, PhD^a, Anetta Undas, MD^a, Piotr Gajewski, MD^a, Pawe Góra, PhD^a, Jakub Swadba, MD^a and Miosz Jankowski, MD^a

^a Departments of Medicine and Physics, School of Medicine, Jagiellonian University, Cracow, Poland

View larger version (43K): [in a new window]   Figure 1 Thrombin generation as a function of time, c(t). co denotes the initial thrombin generation, determines the rate of increase of the curve and S denotes the total amount of thrombin generated in the first 180 s, reflected by the shaded area under the curve.

View larger version (10K): [in a new window]   Figure 2 Thrombin generation expressed as concentrations of prothrombin fragment 1+2 (F1+2) as a function of time, at baseline and after phase I, II and III.