Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy
Cheol Whan Lee, MD*,
Jung-Hee Lee, PhD ,
Jae-Joong Kim, MD*,
Seong-Wook Park, MD, PhD, FACC*,
Myeong-Ki Hong, MD*,
Sang-Tae Kim, BS,
Tae-Hwan Lim, MD, PhD and
Seung-Jung Park, MD, PhD, FACC*
* Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, South Korea
Asan Institute for Life Science, Asan Medical Center, University of Ulsan, Seoul, South Korea
Department of Radiology, Asan Medical Center, University of Ulsan, Seoul, South Korea
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Figure 1 Typical proton magnetic resonance spectroscopy spectra acquired from a parietal white matter region. The creatine peak is significantly reduced in congestive heart failure (arrow) compared with that in a normal control subject. Cho = choline; Cr = creatine; mI = myo-inositol; NAA, N-acetylaspartate.
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Figure 2 Effects of cardiac transplantation on the proton magnetic resonance spectroscopy spectra. Spectra are obtained from an, 18-year-old male patient before and 2 months after successful cardiac transplantation. The creatine peaks in parietal white matter (a) and occipital gray matter (b) are remarkably increased after cardiac transplantation (arrows). The peaks of mI, Cho and NAA in occipital gray matter are slightly increased after cardiac transplantation (b). Cho = choline; Cr = creatine; mI = myo-inositol; NAA = N-acetylaspartate.
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