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Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance

^a Clinic for Internal Medicine/Cardiology, University of Leipzig, Herzzentrum GmbH, Leipzig, Germany

View larger version (134K): [in a new window]   Figure 1 Representative images (x200) of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling reactions or antiactin staining of skeletal muscle biopsies. Nuclei with fragmented deoxyribonucleic acid stained red (arrows) (A) whereas cells with normal nuclei stained blue (immunoperoxidase staining with hematoxylin counterstaining). Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling staining of a skeletal muscle biopsy from a (A) chronic heart failure (CHF) patient; (B) normal control subject; (C) CHF patient after deoxyribonuclease I pretreatment; (D) CHF patient after deoxyribonuclease I pretreatment but with the omission of deoxynucleotidyl transferase in the labeling reaction; (E) CHF patient, and (F) the same as in (E) but counterstained with antiactin is shown. The identical nuclei in E and F are marked with asterisks.

View larger version (145K): [in a new window]   Figure 2 Representative images of the immunohistochemical detection of inducible nitric oxide synthase (A, B) or Bcl-2 (C, D) of a skeletal muscle biopsy from a chronic heart failure patient (A, C) and a normal control subject (C, D) (x200).