EndothelinB receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction
Peter J. Cowburn, MBBS, MRCP*  ,
John G. F. Cleland, MD, FRCP, FESC, FACC ,
John D. McArthur, MB, ChB, FRCP,
Margaret R. MacLean, PhD* ,
John J. V. McMurray, BSc, MD, FRCP, FESC* ,
Henry J. Dargie, MB, ChB, FRCP, FESC* and
James J. Morton, PhD*
* Medical Research Council Clinical Research Initiative in Heart Failure, University of Glasgow, Glasgow, Scotland, United Kingdom
Department of Cardiology, Western Infirmary, Glasgow, Scotland, United Kingdom
The Academic Unit, Department of Cardiology, Kingston-upon-Hull, United Kingdom
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Figure 1 Sequential changes in systemic vascular resistance (SVR) in response to endothelin-1 (ET-1) and endothelin-3 (ET-3) infusion. Compared with baseline measurements, the rise in SVR was significant at a 15 pmol/min dose of ET-1 and ET-3 respectively, *p < 0.01. Repeated measures analysis of variance failed to demonstrate differences between ET-1 and ET-3 or between 5 and 15 min of infusion at each dose.
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Figure 2 Sequential changes in mean plasma endothelin-1 (ET-1) concentration in response to endothelin-1 (ET-1) and endothelin-3 (ET-3) infusion. Compared with baseline values, the rise in plasma ET-1 concentration observed during ET-1 infusion (15 pmol/min) was significant, *p < 0.01. SNP = sodium nitroprusside.
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