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Combined effects of nitric oxide and oxygen during acute pulmonary vasodilator testing

^a Department of Cardiology, Children’s Hospital, Boston, Massachusetts, USA
^b Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
^c Harvard Medical School, Boston, Massachusetts, USA

View larger version (39K): [in a new window]   Figure 1 Pulmonary vascular resistance (PVR) (mean ± SE) differed across the four study conditions in group 1 (p < 0.0001); PVR was lower in oxygen (O2) compared with room air (RA) (*) and was lower in nitric oxide in RA (NO+RA) compared with RA () (p < 0.05 for both).

View larger version (64K): [in a new window]   Figure 2 Individual patients’ percentage change in PVR with O2 is plotted against percentage change in PVR with NO+RA. Using a 20% decrease in PVR as a marker for responsiveness, some patients responded to one drug only. Neither O2 nor NO+RA identified all patients with pulmonary vasoreactivity. Abbreviations as in Figure 1.

View larger version (29K): [in a new window]   Figure 3 Pulmonary vascular resistance (mean ± SE) differed across the three study conditions in group 2 (p < 0.0001); PVR was lower in O2 compared with RA (*) and was lower in NO+O2 compared with RA (*) and O2 () (p < 0.05 for all comparisons). Abbreviations as in Figure 1.