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Endothelium-dependent relaxation by acetylcholine is impaired in hypertriglyceridemic humans with normal levels of plasma LDL cholesterol

^a Alfred and Baker Medical Unit, Baker Medical Research Institute and The Alfred Hospital, Commercial Road, Prahran, Victoria, Australia 3181

View larger version (21K): [in a new window]   Figure 1 Dose-dependent vasodilatory responses to acetylcholine in controls and in patients with hypercholesterolemia and hypertriglyceridemia. Top panel shows responses expressed as absolute forearm blood flow; bottom panel as % increase in basal forearm blood flow. Analysis was by two-way repeated measures (RM) ANOVA followed by Student-Newman-Keuls test (*p < 0.05 when compared to control point). Results are expressed as mean ± standard error of the mean.

View larger version (18K): [in a new window]   Figure 2 Dose-dependent vasodilatory responses to sodium nitroprusside in controls and in patients with hypercholesterolemia and hypertriglyceridemia. Top panel shows responses expressed as absolute forearm blood flow; bottom panel as % increase in basal forearm blood flow. Analysis was by two-way repeated measures (RM) ANOVA followed by Student-Newman-Keuls test (*p < 0.05 when compared to control point). Results are expressed as mean ± standard error of the mean.

View larger version (23K): [in a new window]   Figure 3 Responses are shown before (–20 s) and that obtained immediately (0 s; peak flow) and 20, 40, 60, 80, 100, 120, 140 and 160 s following 5 min of upper arm ischemia. Top panel shows responses expressed as absolute forearm blood flow; bottom panel as % increase in basal forearm blood flow. Analysis was by two-way repeated measures (RM) ANOVA followed by Student-Newman-Keuls test (*p < 0.05 when compared to control point). Results are expressed as mean ± standard error of the mean.

View larger version (28K): [in a new window]   Figure 4 Top panel: Dose-dependent decreases in forearm blood flow are shown in response to noradrenaline in controls and in patients with hypercholesterolemia and hypertriglyceridemia. Analysis was by two-way repeated measures (RM) ANOVA. Bottom panel: The % decrease is shown in basal forearm blood flow following infusion with NG-monomethyl-L-arginine (L-NMMA) 4 µmol/min in controls, hypercholesterolemics and hypertriglyceridemics. Analysis was by one-way ANOVA. Results are expressed as mean ± standard error of the mean.