Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition
A potential role of bradykinin
Abhiram Prasad, MB, MRCPa,
Syed Husain, MDa and
Arshed A. Quyyumi, MD, MRCP, FACCa
a Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1650, USA
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Figure 1 Effects of bradykinin (left) and sodium nitroprusside (right) before (control, •) and after enalaprilat ( ) on epicardial diameter. (Data represent mean ± SEM).
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Figure 2 The effects of cardiac pacing before and after enalaprilat on coronary epicardial segments that initially constricted (left, n = 20) or dilated (right, n = 30) with cardiac pacing. There was no significant difference (p = 0.5) between the mean baseline diameters of constricting segments (2.1 ± 0.1 mm) compared to dilating segments (2.0 ± 0.1 mm). Data represent mean ± SEM.
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Figure 3 The effects of bradykinin (left) and sodium nitroprusside (right) on coronary epicardial segments that constricted or dilated with cardiac pacing. The potentiation of bradykinin by enalaprilat is demonstrated in hatched bars. Data represent mean ± SEM.
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Figure 4 The effects of cardiac pacing before and after 62.5 ng/min of intracoronary bradykinin on coronary epicardial segments which constricted (left) or dilated (right) with control pacing. Data represent mean ± SEM.
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