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Cardiac metaiodobenzylguanidine uptake in patients with moderate chronic heart failure: relationship with peak oxygen uptake and prognosis

Alain Cohen-Solal, MD, PhD, FESC^*, Yves Esanu, MD^*, Damien Logeart, MD^*, Fabienne Pessione, MD^*, Claude Dubois, MD, Gilles Dreyfus, MD, René Gourgon, MD^* and Pascal Merlet, MD, PhD

^* Hôpitaux Beaujon, Clichy, France
Foch, Suresnes, France
Centre Hospitalier Frederic Joliot, Orsay, France

View larger version (22K): [in a new window]   Figure 1 Correlation between late MIBG uptake (MIBG H/M, in percentage) and peak VO2 (in ml/min/kg).

View larger version (17K): [in a new window]   Figure 2 Event-free survival curves according to baseline peak VO2, using a peak VO2 cutoff value of 21 ml/min/kg.

View larger version (18K): [in a new window]   Figure 3 Event-free survival curves according to baseline late MIBG uptake, with a MIBG H/M cutoff value of 127%.

View larger version (19K): [in a new window]   Figure 4 Plot showing ROC curves for prediction of death or cardiac transplantation for peak oxygen uptake (% of predicted values) and late MIBG H/M. Peak oxygen uptake ROC curve, situated clearly leftward relative to MIBG curve, suggests better predictive value.